Big-money signing Casemiro could make his Manchester United debut at Southampton but manager Erik ten Hag says Anthony Martial is out with an Achilles injury.
Thomas Tuchel has questioned how Antonio Conte escaped a touchline ban after the two coaches' red cards in Chelsea's 2-2 draw with Tottenham.
Scott Parker has warned his Bournemouth side to expect a reaction from Liverpool this weekend.
Everton boss Frank Lampard is adamant the club will sign a new striker before next week's transfer window deadline.
Eddie Howe is hoping Alexander Isak with add "the X-factor" to his team as Newcastle close in on a club-record signing.
Leeds head coach Jesse Marsch has not ruled out signing a new striker before the transfer window closes next week.
Southampton boss Ralph Hasenhuttl expects weekend opponents Manchester United to be eyeing silverware this season, despite an unconvincing start to Erik ten Hag's reign.
Gianluca Scamacca has thrust himself into contention to kickstart West Ham's Premier League season after another goal in Europe.
Mikel Arteta believes the current transfer market is tougher than ever, predicting a "very powerful" end to the window, but offered no guarantees Arsenal would sign a replacement for Nicolas Pepe.
Pavol Safranko has returned to his former club following his release from Mamelodi Sundowns this week.