Southampton manager Ralph Hasenhuttl insists in-form striker Che Adams will "definitely not" be sold this summer amid links with Premier League rivals Everton.
Manchester City faces Chelsea while Manchester United will host Aston Villa in the third round of the Carabao Cup.
Newcastle face an anxious wait on two fronts as they attempt to push home a deal for Watford striker Joao Pedro and Callum Wilson heads for a scan.
Barcelona are reportedly not finished in the transfer window as they need a right-back and are looking to make a move on Real Betis target Hector Bellerin.
Liverpool have suffered a fresh injury blow with midfielder Naby Keita facing a further spell on the sidelines.
Thomas Tuchel has been charged with alleged improper conduct over his comments on referee Anthony Taylor after Chelsea's 2-2 Premier League draw with Tottenham.
Jadon Sancho and Marcus Rashford fired Manchester United to a memorable first win under Erik ten Hag as bitter rivals Liverpool were beaten 2-1 on a night of protests against the Glazer family.
Erik ten Hag will stick with his philosophy and plan despite Manchester United's wretched start to the campaign.
Jesus claimed his first Gunners goals since his summer switch from Manchester City by netting twice in last weekend's 4-2 Premier League success over Leicester.
Bournemouth boss Scott Parker will make a late call on striker Dominic Solanke ahead of Saturday evening's Premier League clash with Arsenal.