Masandawana have drawn two consecutive games in the league but bounced back in the Nedbank Cup with a 6-1 demolition of MM Platinum, before a 2-0 win in the CAF Champions League group stage away at Nouadhibou.
The drawn league games have seen their lead at the top of the table shrink to nine points, but they still have two games in hand over second-placed Cape Town City.
On the horizon, a crunch Champions League encounter awaits against TP Mazembe on Saturday, but coach Rulani Mokwena insists he is fully focused on beating AmaZulu first.
“We have a midweek match against AmaZulu because we take it one game at a time,” Mokwena told the media.
“We will see what we have to do against Mazembe, but the first thing is recovery and try to be well prepared for the midweek fixture against AmaZulu.”
Meanwhile, AmaZulu occupy mid-table and will be eyeing a return to victory in the league as well.
The KwaZulu-Natal outfit lost their last Premiership game 3-1 at Cape Town Spurs, but most recently beat Royal AM 1-0 in the Nedbank Cup.
Usuthu are 10th in the league standings but a win could lift them as high as sixth.
The visitors hope to have Abubakar Mobara and Rowen Human available again to face Sundowns.