AmaZulu and TS Galaxy will lock horns at King Zwelithini Stadium on Friday in the Betway Premiership, both eyeing a move into top-three contention.
Usuthu, currently seventh in the league, are winless in their last two outings, having suffered a 2-0 defeat to Mamelodi Sundowns on Tuesday after drawing with SuperSport United.
A victory would take them closer to the top four, where they trail Stellenbosch by just two points.
AmaZulu have no suspension worries, but Augustine Mulenga remains sidelined, having not featured since September due to fitness concerns.
Meanwhile, TS Galaxy arrive in Durban in strong form, unbeaten in their last three matches. The Rockets secured a convincing 3-1 win over SuperSport United on Tuesday, following a draw and a prior victory.
Sitting fifth in the table, they are just two points behind third-placed Sekhukhune United. A win could see them break into the top three, depending on other results.
They are boosted by the return of Victor Letsoalo, who is available after completing a two-match suspension and international duty with Bafana Bafana.