Orlando Pirates will travel to SuperSport United in the Nedbank Cup quarterfinals while Kaizer Chiefs will visit Stellenbosch after the draw was conducted.
Mamelodi Sundowns will face the winner of the Last 32 tie between Royal AM and second-tier Milford FC, who then must take on Sekhukhune United in the Last 16.
The last of the quarterfinal ties will see second-tier Durban City host 2021 winners Marumo Gallants.
The Buccaneers are looking to win the tournament for the third consecutive season but face a tricky test against Gavin Hunt’s charges.
Amakhosi, meanwhile, are still searching for a first trophy in more than decade and will have to travel to the Western Cape for an intriguing ite against Stellies.
Motsepe Foundation Championship club Durban City are the only side not in the top-flight still in the competition and will fance their chances of another upset against Gallants.
The Nedbank Cup Last 8 fixtures are due to be played on the weekend of 7-9 March with venues and dates to be confirmed at a later stage.
Nedbank Cup quarterfinal draw:
Durban City FC v Marumo Gallants
Mamelodi Sundowns v Royal AM v Milford FC/Sekhukhune United
SuperSport United v Orlando Pirates
Stellenbosch FC v Kaizer Chiefs