The Black Stars qualified for the competition as Group I winners ahead of Madagascar, Mali, Comoros, Central African Republic and Chad.
They have, however, lost their last four friendly games, 2-0 to Japan, 1-0 to South Korea and most recently 5-1 to Austria and 2-1 to Germany on Monday night.
Ghana will play co-hosts Mexico and Wales in two final warm-up games ahead of Group L clashes with Panama, England and Croatia when the tournament kicks off in June.
“The Ghana Football Association (GFA) has parted ways with the Head Coach of the senior men’s national team (Black Stars), Otto Addo effective immediately,” read a GFA statement.
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“The Association wishes to thank Otto Addo sincerely for his contribution to the team and wishes him the best of luck in his future endeavours.
“The Ghana Football Association will communicate the new technical direction of the Black Stars in due course.”